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Joe Biden made historic gains fighting street fentanyl, but Donald Trump reframed the drug issue in ways that fuel his domestic and foreign policy agendas.

NASA says a crew member on the International Space Station is unwell. The agency canceled a planned spacewalk for Thursday and is taking the rare step of ending the Crew-11 mission early.

As Minneapolis continued to grapple with a deep divide over how the fatal shooting was being portrayed, police said two people in Portland, Ore., were shot and injured by U.S. Border Patrol agents.

President Trump sidelined Venezuela's opposition and is working with remnants of the regime led by ousted leader Nicolás Maduro. What's next for the opposition?

A total of 34 local infrastructure projects are getting funded. Here's what you need to know.

Did you resolve to read more in 2026? Whether you're on track or need a jump start, here are some books coming out in the next few months to considering adding to your list.

NPR's Steve Inskeep speaks with Minnesota State Sen. Zaynab Mohamed, who represents the Minneapolis district where a woman was fatally shot by an ICE agent Wednesday.

Minnesota state and city leaders condemned the Trump administration's immigration crackdown in Minneapolis following Wednesday's fatal shooting of a 37-year-old woman by an ICE agent.

NPR's Leila Fadel speaks with Minnesota Attorney General Keith Ellison about the deadly shooting of a Minneapolis woman by an ICE officer and the presence of 2,000 ICE agents in the city.

Secretary of State Marco Rubio and Secretary of Defense Pete Hegseth briefed lawmakers Wednesday on the Trump administration's plans for Venezuela.